![]() We believe that sitagliptin provides these added benefits by suppressing free radicals (charged substances that cause damage to the body) and inflammation. On the 4th and 5th days I couldn't even go to work. ![]() I got over fear of giving myself the shot, but on the 3rd day I began to get sick. She wanted me to try Victoza and give up the Januvia. The purpose of this study is to determine if the addition of sitagliptin to diabetic patients will provide added benefit. I have been on Metformin, Januvia and Glimeperide for a few years. We believe that Sitagliptin may exert an anti-inflammatory effect in the human. In this study we want to see the effect of sitagliptin on these markers. Obesity and diabetes are states of increased inflammation and can influence the free radicals and inflammatory markers (chemicals in the blood which increase due to inflammation in the body) and are also major risk factors for atherosclerotic disease. Sitagliptin has been shown to have fewer side effects in the control of blood glucose values. For patients with severe renal impairment (eGFR less than 30 mL/min/1.73 m 2) or with end-stage renal disease (ESRD) requiring hemodialysis or peritoneal dialysis, the dose of JANUVIA is 25 mg once daily. Sitagliptin is a new oral hypoglycemic anti-diabetic drug used either alone or in combination with metformin or a thiazolidinedione for control of type 2 diabetes mellitus. Why Should I Register and Submit Results?.
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